P4-073: Gamma-Secretase is Present at Both Sides of the Neuronal Synapse
نویسندگان
چکیده
منابع مشابه
Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse
The transmembrane protein assembly γ-secretase is a key protease in regulated intramembrane processing (RIP) of around 100 type-1 transmembrane proteins. Importantly, it has a pathological role in Alzheimer disease (AD) as it generates the neurotoxic amyloid β-peptide from the amyloid precursor protein (APP). Studies on γ-secretase location are therefore crucial both from a biological and a the...
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Editor's Note: These short, critical reviews of recent papers in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to summarize the important findings of the paper and provide additional insight and commentary. For more information on the format and purpose of the Journal Club, please see Review of Chung et al. At least three distinct forms of synaptic ...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2016
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2016.06.2163